Cadmium content in selected rat tissues following treatments with cadmium chloride and/or gamma radiation
This study was conducted to determine concentrations of cadmium (Cd) in various rat tissues; radiation effectiveness on Cd concentrations in rat tissues; and Cd effectiveness when radiation was applied as the second insult. Animals were subjected to Cd over a 29-day period and on Day 30 were exposed to an acute dose of /sup 60/Co gamma-ray. Rats were killed on Day 1, 7, or 21 following irradiation. Cd concentrations were determined by flame spectroscopy. Rats injected with Cd alone or Cd in combination with radiation showed a dose-dependent accumulation and retention of the metal in the liver and kidney over the intervals to sacrifice. Significantly smaller amounts of the metal were seen in the spleen, intestine, stomach, heart, testis, lung, blood, brain, and muscle. Generally, Cd did not afford protection against radiation in the tissues studied. Radiation, when used singly or as a coinsult with Cd, did not significantly alter the concentrations of Cd in any of the tissues studied except the heart, in which it contributed to the clearance of Cd. No synergistic or antagonistic effects were observed between Cd and ionizing radiation in any of the other tissues studied.
- Research Organization:
- Texas Woman's Univ., Denton
- OSTI ID:
- 5267804
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
CADMIUM
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTROMAGNETIC RADIATION
ELEMENTS
GAMMA RADIATION
GLANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER
MAMMALS
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOBIOLOGY
RADIOISOTOPES
RATS
RETENTION
RODENTS
SYNERGISM
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES