Physico-chemical studies of radiation effects in cells. Progress report, February 15, 1984-February 14, 1985

Technical Report · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5265381

Powers, E L

The radioprotective effects of Hg/sup + +/ were investigated in Staphylococcus aureus and Pseudomonas aeruginosa bacteria having very different gc ratios in their DNA. A protective effect is seen in both with first order curves or at least in the k/sub L/ region of the breakpoints. However, it is curious that there is a distinct difference in the metal-free N/sub 2/ baseline of Staphylococcus aureus compared to its EtOH metal-free N/sub 2/ response while with Pseudomonas aeruginosa both the metal-free N/sub 2/ baseline and its EtOH metal-free results are similar. In related studies a new radioprotective substance was evaluated in bacterial systems. Results showed that, in the presence of Rh(NH/sub 3/)/sub 3/C//sub 3/, the anoxic cell shows greater sensitivity than the oxygenated cell. This compound has considerable therapeutic promise providing it acts the same on mammalian cells. 8 refs., 6 figs. (DT)

• Research Organization: Texas Univ., Austin (USA). Lab. of Radiation Biology
• DOE Contract Number: AS05-76EV03408
• OSTI ID: 5265381
• Report Number(s): DOE/EV/03408-T1; ON: DE85014681
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOXIA
BACTERIA
DATA
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
MERCURY
METALS
MICROORGANISMS
NUMERICAL DATA
PSEUDOMONAS
RADIOSENSITIVITY EFFECTS
REFRACTORY METAL COMPOUNDS
RHODIUM COMPOUNDS
SILVER
STAPHYLOCOCCUS
SURVIVAL CURVES
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS