Physico-chemical studies of radiation effects in cells. Progress report, November 15, 1980-February 14, 1984

Technical Report · Sat Jan 01 04:00:00 EST 1983

OSTI ID:5622388

Powers, E L

The primary interest is investigating and understanding the chemical mechanisms involved in radiation-induced cellular damage. Most recently the perturbating devices have been metals which increase, in various ways and modes, the radiation sensitivity of several cell types. While the chief cell type has been the bacterial spore, chosen because of its biological inertness and its hardiness, allowing it to survive the unphysiological conditions of the physical chemist and, thus, inquiry into the free radical mechanisms involved very soon after energy absorption, recently vegetative cells have been introduced. A number of metals have been used and practically all of them sensitize - but to varying degrees. Straight biological techniques such as the measurement of cell survival under various conditions in the different cells have been used, as well as parallel experiments in pulse radiolysis to attack the specific leads in a chemical fashion suggested by the biology.

• Research Organization: Texas Univ., Austin (USA). Lab. of Radiation Biology
• DOE Contract Number: AS05-76EV03408
• OSTI ID: 5622388
• Report Number(s): DOE/EV/03408-27; ON: DE84001512
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BACTERIAL SPORES
ELEMENTS
ESCHERICHIA COLI
METALS
MICROORGANISMS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
SPORES
SURVIVAL CURVES