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Title: Copper, iron and zinc absorption, retention and status of young women fed vitamin B-6 deficient diets

Abstract

A study was conducted in young women to determine the effect of vitamin B-6 deficient diets on copper, iron and zinc metabolism. Young women were confined to a metabolic research unit for 84 and 98 days. They were fed a vitamin B-6 deficient formula diet initially, followed by food diet containing four increasing levels of vitamin B-6. Copper, iron and zinc absorption, retention and status were determined at intervals throughout the study. Absorption was determined using the stable isotopes {sup 65}Cu, {sup 54}Fe, and {sup 67}Zn. Status was based on serum copper and zinc, hemoglobin, hematocrit and mean corpuscular volume. Copper absorption averaged 18 {plus minus} 1% during vitamin B-6 depletion, significantly lower than 24 {plus minus} 1% during repletion, but serum copper was not affected and balance was positive. Iron absorption was not impaired significantly by vitamin B-6 deficient diets, but status declined during the depletion period. Zinc absorption averaged 40 {plus minus} 2% during depletion and 27 {plus minus} 2% during repletion. Zinc absorption and retention were significantly greater during vitamin B-6 depletion, but serum zinc declined suggesting the absorbed zinc was not available for utilization. The results suggest that vitamin B-6 depletion of young women may inhibitmore » copper absorption, affect iron status and alter zinc metabolism. The effects of vitamin B-6 depletion differ markedly among these elements.« less

Authors:
; ; ; ; ;  [1]
  1. (USDA/ARS, San Francisco, CA (United States) Western Regional Research Center, Albany, CA (United States))
Publication Date:
OSTI Identifier:
5265355
Alternate Identifier(s):
OSTI ID: 5265355
Report Number(s):
CONF-9104107--
Journal ID: ISSN 0892-6638; CODEN: FAJOE
Resource Type:
Conference
Journal Name:
FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
Additional Journal Information:
Journal Volume: 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; Journal ID: ISSN 0892-6638
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; COPPER; METABOLISM; IRON; VITAMIN B GROUP; BIOLOGICAL EFFECTS; ZINC; ABSORPTION; BLOOD COUNT; COPPER 65; DIET; HEMOGLOBIN; INHIBITION; IRON 54; RETENTION; TRACER TECHNIQUES; WOMEN; ZINC 67; ANIMALS; CARBOXYLIC ACIDS; COPPER ISOTOPES; ELEMENTS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; FEMALES; GLOBINS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MAN; METALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PIGMENTS; PORPHYRINS; PRIMATES; PROTEINS; STABLE ISOTOPES; TRANSITION ELEMENTS; VERTEBRATES; VITAMINS; ZINC ISOTOPES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Turnlund, J.R., Keyes, W.R., Hudson, C.A., Betschart, A.A., Kretsch, M.J., and Sauberlich, H.E. Copper, iron and zinc absorption, retention and status of young women fed vitamin B-6 deficient diets. United States: N. p., 1991. Web.
Turnlund, J.R., Keyes, W.R., Hudson, C.A., Betschart, A.A., Kretsch, M.J., & Sauberlich, H.E. Copper, iron and zinc absorption, retention and status of young women fed vitamin B-6 deficient diets. United States.
Turnlund, J.R., Keyes, W.R., Hudson, C.A., Betschart, A.A., Kretsch, M.J., and Sauberlich, H.E. Mon . "Copper, iron and zinc absorption, retention and status of young women fed vitamin B-6 deficient diets". United States.
@article{osti_5265355,
title = {Copper, iron and zinc absorption, retention and status of young women fed vitamin B-6 deficient diets},
author = {Turnlund, J.R. and Keyes, W.R. and Hudson, C.A. and Betschart, A.A. and Kretsch, M.J. and Sauberlich, H.E.},
abstractNote = {A study was conducted in young women to determine the effect of vitamin B-6 deficient diets on copper, iron and zinc metabolism. Young women were confined to a metabolic research unit for 84 and 98 days. They were fed a vitamin B-6 deficient formula diet initially, followed by food diet containing four increasing levels of vitamin B-6. Copper, iron and zinc absorption, retention and status were determined at intervals throughout the study. Absorption was determined using the stable isotopes {sup 65}Cu, {sup 54}Fe, and {sup 67}Zn. Status was based on serum copper and zinc, hemoglobin, hematocrit and mean corpuscular volume. Copper absorption averaged 18 {plus minus} 1% during vitamin B-6 depletion, significantly lower than 24 {plus minus} 1% during repletion, but serum copper was not affected and balance was positive. Iron absorption was not impaired significantly by vitamin B-6 deficient diets, but status declined during the depletion period. Zinc absorption averaged 40 {plus minus} 2% during depletion and 27 {plus minus} 2% during repletion. Zinc absorption and retention were significantly greater during vitamin B-6 depletion, but serum zinc declined suggesting the absorbed zinc was not available for utilization. The results suggest that vitamin B-6 depletion of young women may inhibit copper absorption, affect iron status and alter zinc metabolism. The effects of vitamin B-6 depletion differ markedly among these elements.},
doi = {},
journal = {FASEB Journal (Federation of American Societies for Experimental Biology); (United States)},
issn = {0892-6638},
number = ,
volume = 5:4,
place = {United States},
year = {1991},
month = {3}
}

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