Intraprostatic injection of neutralized zinc in rats
- Univ. of Missouri, Columbia (United States) Xian Medical University (China)
Zinc has been implicated in steroid endocrinology of the prostate gland. The conversion of testosterone to dihydrotestosterone (DHT) by 5{alpha}-reductase enzyme is believed to express androgenic responses in the prostate. To note the effect of neutralized zinc on the prostate, 50 sexually mature rats, weighing 325 {plus minus} 20 grams, were divided into 5 groups as follows: (1) control, (2) sham, (3) castrated, (4) injected intraprostatically with 10 mg. neutralized zinc, and (5) injected intraprostatically with 20 mg. neutralized zinc. Results in the treated groups indicated significant reduction of prostate weights, 12% and 53% and histologically normal prostate; no significant change in weight and histological structure of testes, epididymides, and seminal vesicles; significant reduction in 5{alpha}-reductase activity and total protein and DNA concentrations in prostate tissue; and no significant effect on progeny of treated animals. These results suggest that direct application of neutralized zinc to the prostate offers a new modality for treatment of prostatitis without affecting spermatogenesis and testosterone production.
- OSTI ID:
- 5264568
- Report Number(s):
- CONF-9104107--
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:4; ISSN FAJOE; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
Similar Records
Reproductive and endocrinological features of male rats after treatment with cadmium chloride
Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL EFFECTS
BODY
DISEASES
ELEMENTS
ENDOCRINE DISEASES
ENZYMES
GLANDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MALE GENITALS
MAMMALS
METABOLISM
METALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROSTATE
PROTEINS
RATS
RODENTS
SENSITIVITY
STEROID HORMONES
STEROIDS
TESTOSTERONE
VERTEBRATES
ZINC