Neuroblastoma: A neurochemical approach

Journal Article · Mon Jul 01 04:00:00 EDT 1991 · Journal of Child Neurology; (United States)

DOI:https://doi.org/10.1177/088307389100600303· OSTI ID:5263737

Schor, N F ^[1]

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1. Children's Hospital of Pittsburgh, PA (USA)

Neuroblastoma is among the most common malignancies of childhood. Despite greatly improved therapy for some pediatric tumors, the prognosis for children with metastatic neuroblastoma has not changed significantly in the past 10 years. With conventional chemotherapy, radiation therapy, and surgery, children with metastatic neuroblastoma have a 20% long-term survival rate. The authors describe here approaches to neuroblastoma that target its neuronal characteristics. On the one hand, the neurotransmitter receptors on the surface of the neuroblastoma cells and, on the other hand, specific isozymes that distinguish neuroblastoma cells from their normal counterparts are the focus of these experimental therapies. In the former case, specificity for tumor cells is effected by (1) selective protection of normal neuronal elements from toxicity, or (2) selective potentiation of toxicity for neural tumor cells. It is hoped that these strategies will be generalizable to other neural crest-derived tumors. 32 references.

• OSTI ID: 5263737
• Journal Information: Journal of Child Neurology; (United States), Journal Name: Journal of Child Neurology; (United States) Vol. 6:3; ISSN JOCNE; ISSN 0883-0738
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHILDREN
DISEASES
DOPAMINE
DRUGS
ELECTROPHYSIOLOGY
HYDROXY COMPOUNDS
MAMMALS
MEDICINE
MICE
NEOPLASMS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
PATIENTS
PHENOLS
PHYSIOLOGY
POLYPHENOLS
RADIOLOGY
RADIOTHERAPY
RODENTS
SURGERY
SURVIVAL CURVES
SYMPATHOMIMETICS
THERAPY
VERTEBRATES