Synaptonemal complex analysis in genetic toxicology
Technical Report
·
OSTI ID:5263247
Synaptonemal complex analysis provides a unique means of visualizing the behavior of meiotic chromosomes. The technique has been applied to the study of normal karyotypes and mutant stocks of mice. Recent work demonstrating the usefulness of SC analysis for the detection of chromosome damage suggests its potential application in a variety of mechanistic and applied studies. Studies investigated cell-stage specific damage included by radiation and expressed as SC and/or metaphase chromosome aberrations. Radiation was found to exhibit a similar stage-specific clastogenic activity for SCs as it does for meiotic metaphase chromosomes. The nature of the chromosome damage detected depend upon the cell stage exposed and on the endpoint harvested for analysis.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5263247
- Report Number(s):
- PB-90-119249/XAB; EPA--600/D-89/155
- Country of Publication:
- United States
- Language:
- English
Similar Records
Stage-specific damage to synaptonemal complexes and metaphase chromosomes induced by X rays in male mouse germ cells
Stage-specific damage to synaptonemal complexes and metaphase chromosomes induced by X rays in male mouse germ cells
Identification of aberrant chromosomes on the basis of morphometry of synaptonemal complexes in the sterile male mouse
Technical Report
·
Mon Dec 31 23:00:00 EST 1990
·
OSTI ID:5733284
Stage-specific damage to synaptonemal complexes and metaphase chromosomes induced by X rays in male mouse germ cells
Journal Article
·
Thu Jan 31 23:00:00 EST 1991
· Radiation Research; (USA)
·
OSTI ID:5891134
Identification of aberrant chromosomes on the basis of morphometry of synaptonemal complexes in the sterile male mouse
Journal Article
·
Sat Dec 31 23:00:00 EST 1988
· Sov. Genet. (Engl. Transl.); (United States)
·
OSTI ID:6036704
Related Subjects
550400* -- Genetics
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CELL DIVISION
CHROMOSOMAL ABERRATIONS
DOSE-RESPONSE RELATIONSHIPS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GENETICS
MAMMALS
MEIOSIS
MICE
MUTATIONS
RADIATION EFFECTS
RODENTS
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
CELL DIVISION
CHROMOSOMAL ABERRATIONS
DOSE-RESPONSE RELATIONSHIPS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GENETICS
MAMMALS
MEIOSIS
MICE
MUTATIONS
RADIATION EFFECTS
RODENTS
VERTEBRATES