Deep vein thrombosis: scintigraphic diagnosis with In-111-labeled monoclonal antifibrin antibodies

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.173.2.2678259· OSTI ID:5261614

Jung, M; Kletter, K; Dudczak, R; Koppensteiner, R; Minar, E; Kahls, P; Stuempflen, A P; Pokieser, P; Ehringer, H ^[1]

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1. Univ. of Vienna Medical School (Austria)

Fifty-two patients suspected of having deep vein thrombosis under-went scintigraphy with an indium-111-labeled monoclonal antifibrin antibody. Venography disclosed deep vein thrombosis in 31 patients. With the whole limb considered an anatomic entity, antifibrin antibody scintigrams obtained 2 hours after injection had a specificity and sensitivity of 81% and 84%, respectively. A higher sensitivity (92%) was found for a subgroup of patients (n = 44) with symptoms for less than 10 days. Regional sensitivities for all patients and for the subgroup, respectively, were 92% and 100% in the calf, 82% and 94% in the popliteal region, 63% and 71% in the thigh, and only 18% and 13% in the pelvis. Additional imaging performed 6 hours and 21 hours after injection in 12 patients and quantitative analysis done from scintigrams with and without blood-pool (technetium-99m human serum albumin) correction did not improve sensitivity. In-111-antifibrin antibody scintigraphy is an accurate method for diagnosis of acute established deep vein thrombosis of the calf and popliteal region; its sensitivity in the thigh is lower, and it is not feasible for diagnosis in the pelvic area.

• OSTI ID: 5261614
• Journal Information: Radiology; (USA), Journal Name: Radiology; (USA) Vol. 173:2; ISSN 0033-8419; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
COAGULANTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FIBRIN
HEMATOLOGIC AGENTS
HEMOSTATICS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEGS
LIMBS
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PROTEINS
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SCLEROPROTEINS
SENSITIVITY ANALYSIS
THROMBOSIS
TRACER TECHNIQUES
VASCULAR DISEASES