Synthetic approaches to a carboranyl thiouracil

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Pigment Cell Research; (USA)

DOI:https://doi.org/10.1111/j.1600-0749.1989.tb00208.x· OSTI ID:5261452

Wilson, J G ^[1]

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1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales

Thiouracil is selectively incorporated into melanotic murine melanomas during melanin synthesis. This selectivity makes thiouracil a likely vehicle for boron in the diagnosis and therapy of melanoma. Several synthetic routes to thiouracils bearing an alkyl decacarboranyl group attached to various positions on the ring have been investigated. The successful syntheses of three new alkynyl thiouracils and the conversion of one of them into a carboranyl thiouracil are described.

• OSTI ID: 5261452
• Journal Information: Pigment Cell Research; (USA), Journal Name: Pigment Cell Research; (USA) Vol. 2:4; ISSN 0893-5785; ISSN PCREE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIMETABOLITES
ANTITHYROID DRUGS
AZINES
BORON COMPOUNDS
CHEMICAL PREPARATION
DISEASES
DRUGS
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC COMPOUNDS
HORMONE ANTAGONISTS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MELANIN
MELANOMAS
MICE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PIGMENTS
PYRIMIDINES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RODENTS
SYNTHESIS
THERAPY
THIOLS
THIOURACIL
UPTAKE
URACILS
VERTEBRATES