Boron-containing thiouracil derivatives for neutron-capture therapy of melanoma

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Journal of Medicinal Chemistry; (USA)

DOI:https://doi.org/10.1021/jm00105a049· OSTI ID:6054873

Tjarks, W; Gabel, D ^[1]

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1. Univ. of Bremen (Germany, F.R.)

Boron-containing derivatives of 2-thiouracil and 2,4-dithiouracil and the corresponding 6-propyl compounds, containing a dihydroxyboryl group in the 5-position, have been prepared. These compounds accumulate in B16 melanoma in mice in concentrations up to 30 micrograms of boron per gram tissue. The uptake persists. The toxicity of both 2-thiouracil derivatives is low. These compounds are therefore good candidates for boron neutron-capture therapy of malignant melanoma.

• OSTI ID: 6054873
• Journal Information: Journal of Medicinal Chemistry; (USA), Vol. 34:1; ISSN 0022-2623
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
NEUTRON CAPTURE THERAPY
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
BORON COMPOUNDS
EXPERIMENTAL NEOPLASMS
MICE
STRUCTURE-ACTIVITY RELATIONSHIPS
ANIMALS
DISEASES
DRUGS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
RADIOLOGY
RADIOTHERAPY
RODENTS
SYNTHESIS
THERAPY
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)