Molecular mechanisms of carcinogenesis
- Columbia Univ., New York, NY (United States)
The possibility that chromosomal changes are responsible for neoplasia was proposed in the early years of this century. A combination of improved cytogenetics and the advent of recombinant technology has settled the issue. As recently as 20 years ago, however, the genetic and molecular basis of familiar predisposition to cancer were a mystery, and it is only in the last few years that light has been shed on a few specific types of malignancies. As the genetic basis of human cancer had been documented, a number of genes have been identified as functioning either as oncogenes which act in a dominant fashion to promote tumor growth when mutated, or as tumor suppressor genes which act in a recessive fashion.
- Research Organization:
- National Council on Radiation Protection and Measurements, Bethesda, MD (United States)
- OSTI ID:
- 526026
- Report Number(s):
- CONF-960405-; TRN: 98:008239
- Resource Relation:
- Conference: 32. annual meeting of the National Council on Radiation Protection and Measurements, Arlington, VA (United States), 3-4 Apr 1996; Other Information: PBD: 1 Mar 1997; Related Information: Is Part Of Implications of new data on radiation cancer risk. Proceedings No. 18; Boice, J.D. Jr. [ed.]; PB: 320 p.
- Country of Publication:
- United States
- Language:
- English
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