Rapid miniaturized chromatographic quality control procedures for iodinated radiopharmaceuticals

Journal Article · Sat Apr 01 04:00:00 EST 1978 · Am. J. Hosp. Pharm.; (United States)

OSTI ID:5254307

Zimmer, A M; Pavel, D G

A rapid, miniaturized chromatographic system was developed to determine the labeling efficiency of iodinated radio-pharmaceuticals including /sup 131/I orthoiodohippurate, /sup 131/I rose bengal, /sup 125/I RISA, and /sup 131/I 19-iodocholesterol. The system consists of three specific chromatography strips (Whatman 31ET paper chromatography, silica gel and silicic acid instant thin-layer chromatography) and three solvents (chloroform:glacial acetic acid in a 1.00:0.05 v/v mixutre, absolute methanol, and 0.9% sodium chloride). The strips are color-coded, miniaturized, and appropriately labeled. The chromatographic quality control procedures are easy to use, rapid, and can be incorporated easily in a routine quality control program.

• Research Organization: Univ. of Illinois at the Medical Center, Chicago
• OSTI ID: 5254307
• Journal Information: Am. J. Hosp. Pharm.; (United States), Journal Name: Am. J. Hosp. Pharm.; (United States) Vol. 35:4; ISSN AJHPA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400100* -- Analytical & Separations Chemistry
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DRUGS
DYES
ELEMENTS
HALOGENATION
HALOGENS
HYDROXY ACIDS
INDICATORS
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
REAGENTS
ROSE BENGAL
SEPARATION PROCESSES
USES