Discrepancy in XC and oncogenicity assays for murine leukemia virus in AKR mice
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:5248150
Studies of murine leukemia virus expression in AKR mice are presented. Material from in vivo and in vitro sources of normal tissues and lymphomas was assayed for in vitro infectivity, using the XC plaque assay, and for oncogenicity, by assessing lymphoma-accelerating capacity after inoculatin into newborn animals. These findings are interpreted as showing the presence of two viruses in AKR mice. One is XC positive and present throughout life. The other is oncogenic, appears later in life, and could be a separate virus or a variant of the first one.
- Research Organization:
- Univ. of California, Los Angeles
- OSTI ID:
- 5248150
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 37; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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