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Tobacco constituents are mitogenic for arterial smooth-muscle cells

Journal Article · · Am. J. Pathol.; (United States)
OSTI ID:5242721
; ;
Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.
Research Organization:
Cornell Univ. Medical College, New York, NY
OSTI ID:
5242721
Journal Information:
Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 1; ISSN AJPAA
Country of Publication:
United States
Language:
English

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Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL CELLS
ANIMALS
ANTIGENS
AROMATICS
ARTERIES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CATTLE
CELL PROLIFERATION
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
DOMESTIC ANIMALS
FIBROBLASTS
FLAVENOIDS
FLAVONES
GLUCOPROTEINS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
MAMMALS
MITOGENS
MUSCLES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PHENOLS
POLYMERS
POLYPHENOLS
PROTEINS
PYRANS
QUERCETIN
RESIDUES
RUMINANTS
SACCHARIDES
SMOKES
SOLS
SOMATIC CELLS
STRUCTURE-ACTIVITY RELATIONSHIPS
TAR
TOBACCO
TOBACCO SMOKES
VERTEBRATES