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Effects of irradiation on macrophagic response and transport of particles across the alveolar epithelium

Journal Article · · Am. J. Pathol.; (United States)
OSTI ID:5238298
;
Macrophagic production and particulate penetration into the lung were studied in mice depleted of monocytes by whole body irradiation. Subsequent intratracheal instillation of 4 mg carbon resulted in a much smaller adaptive increase in the number of alveolar macrophages, as compared with nonirradiated animals. The decreased macrophagic output was associated with increased passage of free carbon across the Type 1 alveolar epithelium in increased accumulation of carbon in interstitial macrophages and hilar lymph nodes of irradiated mice. The results suggest that interference with the adaptive outpouring of alveolar macrophages following a particulate load facilitates the interaction of particles with macrophages within the pulmonary interstitium, where fibrogenic factors released in response to toxic agents would have a maximum effect.
Research Organization:
Univ. of Manitoba, Faculty of Medicine, Winnipeg
OSTI ID:
5238298
Journal Information:
Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 106:1; ISSN AJPAA
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON
CONNECTIVE TISSUE CELLS
DYNAMIC FUNCTION STUDIES
ELEMENTS
EXTERNAL IRRADIATION
IMMUNE REACTIONS
IRRADIATION
LEUKOCYTES
LUNGS
MACROPHAGES
MAMMALS
MATERIALS
MICE
MONOCYTES
NONMETALS
ORGANS
PATHOLOGY
PHAGOCYTES
RADIATION EFFECTS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION