Radioimmunodetection of human melanoma with indium-111-labeled monoclonal antibody

Journal Article · Tue Mar 01 04:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:5237684

Taylor, A Jr; Milton, W; Eyre, H P; Christian, P; Wu, F; Hagan, P; Alazraki, N; Datz, F L; Unger, M

The purpose of the study was threefold: (1) to evaluate the efficacy of an /sup 111/In-labeled murine monoclonal antibody (ZME-018) directed against a heavy molecular weight melanoma associated glycoprotein in localizing metastatic disease; (2) to determine the effect of unlabeled antibody mass (2.5, 5, 10, 20, and 40 mg) on labeled antibody blood clearance, biodistribution and lesion detection; (3) to estimate radiation dosimetry. Twenty-five patients with previously documented disease received an intravenous infusion of 2.5 to 40 mg of monoclonal antibody with 1 mg of the antibody labeled with 5 mCi of /sup 111/In. There were no acute reactions. Patients were scanned without computer enhancement or background subtraction techniques at 24 and 72 hr after injection. Imaging detected tumor in 14/18 (78%) patients with active disease, identified 24/44 (77%) of lesions greater than 1 cm and changed or specifically directed patient management in 22% (4/18) patients with tumor. There was a prolongation in blood clearance associated with decreased liver and spleen activity following administration of 20 and 40 mg of antibody compared to the three lower antibody dose levels. Assuming a biodistribution similar to (/sup 111/In)ZME-018, the radiation dose delivered to normal tissues by (90Y)ZME-018 would restrict its use as a routine vehicle for radioimmunotherapy; however, it may be possible to deliver substantial tumor doses in selected patients.

• Research Organization: Univ. of Utah, Salt Lake City (USA)
• OSTI ID: 5237684
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
CARBOHYDRATES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GLUCOPROTEINS
IMMUNOASSAY
IMMUNOLOGY
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
MAMMALS
MAN
MELANOMAS
METASTASES
MINUTES LIVING RADIOISOTOPES
MOLECULAR WEIGHT
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
SACCHARIDES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES