Radioimmunodetection of human melanoma with indium-111-labeled monoclonal antibodies
Our purpose in conducting this study was to evaluate the efficacy of an /sup 111/In-labeled murine monoclonal antibody directed against a high-molecular-weight glycoprotein in localizing metastatic melanoma in 15 patients with previously documented disease and to determine the effect of antibody mass (2.5, 5.0, and 10.0 mg) on blood clearance, biodistribution, and lesion detection. Five mCi of /sup 111/In-antibody were infused over 1 hour, and patients were scanned at 24 and 72 hours after injection without computer enhancement or background subtraction techniques. No significant differences in the organ distribution, urine excretion, or plasma disappearance curves were noted at the three antibody dose levels. There were no acute reactions. The scan detected tumor in 9 of 12 (75%) patients with active disease, and 26 of 33 (79%) lesions greater than 1 cm. Patient management in 3 of 15 (20%) of patients studied was changed as a result.
- Research Organization:
- Univ. of Utah Health Sciences Center, Salt Lake City
- OSTI ID:
- 6616373
- Journal Information:
- NCI Monogr.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Sequential use of indium-111 labeled monoclonal antibodies 96. 5 and ZME-018 does not increase detection sensitivity for metastatic melanoma
Radioimmunoimaging in malignant melanoma patients with the use of indium-111-labeled antimelanoma monoclonal antibody (ZME-018) to high-molecular-weight antigen
Related Subjects
MELANOMAS
DIAGNOSIS
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
LABELLING
EXCRETION
INDIUM 111
METASTASES
PATIENTS
SCINTISCANNING
TISSUE DISTRIBUTION
URINE
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
USES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics