Synthesis of no-carrier-added alpha-(/sup 11/C)methyl-L-tryptophan

Journal Article · Tue Mar 01 04:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:5237630

Chaly, T; Diksic, M

Described here is a synthesis of no-carrier-added alpha-(/sup 11/C)methyl-L-tryptophan based on alkylation with /sup 11/CH/sub 3/I of an anion generated by reacting the Schiff base of L-tryptophan methyl ester with di-isopropylamine. The synthesis requires approximately 30 min after the end of /sup 11/CO/sub 2/ collection and gives alpha-(/sup 11/C)methyl-L-tryptophan in a 20-25% radiochemical yield calculated at the end of the synthesis and without correction for radioactive decay. The specific activity of the final radiopharmaceutical, measured at the end of the synthesis, was around 2000 Ci/mmol. Data confirming the stereospecificity of the synthesis are also presented.

• Research Organization: Montreal Neurological Institute and Hospital (Canada)
• OSTI ID: 5237630
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
AROMATICS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
DRUGS
EVEN-ODD NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMINES
INDOLES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCHIFF BASES
SYNTHESIS
TRYPTOPHAN