Ontogeny of thymic independent antibody responses in vitro in normal mice and mice with an x-linked B cell defect
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5237306
The primary in vitro antibody response of neonatal spleen cells to three thymic independent antigens has been examined. The time of onset of responsiveness to TNP-Brucella abortus and TNP-lipopolysaccharide was significantly earlier than the onset of responsiveness to TNP-Ficoll. This ontologic sequence was not affected by T cell depletion or antigen presentation on adult macrophages. In neonatal mice bearing the X-linked CBA/N defect, the response to TNP-Brucella abortus and TNP-lipopolysaccharide was much delayed and no response to TNP-Ficoll developed. We conclude that different thymic independent antigens address different subpopulations of B cells, one of which appears earlier in ontogeny than the other.
- Research Organization:
- National Inst. of Health, Bethesda, MD
- OSTI ID:
- 5237306
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 119:6; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRUCELLA
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHATIC SYSTEM
MACROPHAGES
MAMMALS
MICE
MICROORGANISMS
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
POLYSACCHARIDES
RADIATION EFFECTS
RODENTS
SACCHARIDES
SOMATIC CELLS
SPLEEN CELLS
THYMUS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRUCELLA
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
IMMUNE REACTIONS
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHATIC SYSTEM
MACROPHAGES
MAMMALS
MICE
MICROORGANISMS
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
POLYSACCHARIDES
RADIATION EFFECTS
RODENTS
SACCHARIDES
SOMATIC CELLS
SPLEEN CELLS
THYMUS
VERTEBRATES