Response of cultured 9L cells to spirohydantoin mustard and x-rays
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5237223
Rat brain tumor cells (9L) were treated in vitro for 1 hr with 2 ..mu..g/ml (approx. 30% survival) of spirohydantoin mustard (SHM) 4 and 24 hr before, during, and 4 and 24 hr after graded doses of radiation (0-20 Gy). The resulting survival curves generated from colony formation data and corrected for drug kill indicate that for all schedules SHM enhanced the radiation response, particularly for surviving fractions greater than 0.5. Analysis of the combination data using isobolograms indicates the effects of the separate agents were additive in producing either 1, 2, or 3 log cell kills. Therefore, the enhancement of the radiation response by SHM can be explained solely on the basis of the shapes of the single agent survival curves.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5237223
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CELL KILLING
CENTRAL NERVOUS SYSTEM
COLONY FORMATION
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
EXPERIMENTAL DATA
INFORMATION
ISOLATED VALUES
L CELLS
MAMMALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
VERTEBRATES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CELL KILLING
CENTRAL NERVOUS SYSTEM
COLONY FORMATION
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
EXPERIMENTAL DATA
INFORMATION
ISOLATED VALUES
L CELLS
MAMMALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TOXICITY
VERTEBRATES