Radiosensitization of hypoxic tumor cells by cis- and trans-dichlorodiammineplatinum (II)
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5236214
- Dartmouth-Hitchcock Medical Center, Hanover, NH
The effects of the chemotherapeutic agent cis-dischlorodiammineplatinum (II) or its trans isomer on tumor cell lethality were evaluated following administration of the drugs, alone, or in combination with x-irradiation. The tumor latency method was employed to assay tumor cell survival under in vivo growth conditions following treatment in vivo. Radiosensitization of hypoxic tumor cells was demonstrated by combinations of either complex with high doses of radiation. The results extend an effect observed in bacterial systems and cultured mammalian cells to include tumor cells treated in situ. However, therapeutic potentiation during more clinically relevant treatment protocols in air-breathing mice is probably the result of the platinum complexes inhibiting recovery processes following irradiation.
- OSTI ID:
- 5236214
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
- Country of Publication:
- United States
- Language:
- English
Similar Records
Synergistic chemical radiosensitization of hypoxic mammalian cells
Tumor radiosensitization with concomitant bone marrow radioprotection: a study in mice using diethyldithiocarbamate (DDC) under oxygenated and hypoxic conditions
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles. [X radiation]
Journal Article
·
Wed Dec 31 23:00:00 EST 1975
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:7118374
Tumor radiosensitization with concomitant bone marrow radioprotection: a study in mice using diethyldithiocarbamate (DDC) under oxygenated and hypoxic conditions
Journal Article
·
Sat Jun 01 00:00:00 EDT 1985
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5444468
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles. [X radiation]
Journal Article
·
Sun May 01 00:00:00 EDT 1977
· Radiat. Res.; (United States)
·
OSTI ID:7106899
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPLEXES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GLANDS
GROWTH
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LATENCY PERIOD
MAMMALS
MAMMARY GLANDS
MICE
NUMERICAL DATA
ORGANS
PLATINUM COMPLEXES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
TRANSITION ELEMENT COMPLEXES
TUMOR CELLS
VERTEBRATES
X RADIATION
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPLEXES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GLANDS
GROWTH
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LATENCY PERIOD
MAMMALS
MAMMARY GLANDS
MICE
NUMERICAL DATA
ORGANS
PLATINUM COMPLEXES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
TRANSITION ELEMENT COMPLEXES
TUMOR CELLS
VERTEBRATES
X RADIATION