Persistent chromosome damage induced by localized radiotherapy for lymphoma
Journal Article
·
· Cancer Genet. Cytogenet.; (United States)
A fibroblast culture was established from a lymph node biopsy of a patient with non-Hodgkin lymphoma, 9 months after chemotherapy and intensive therapeutic x-irradiation of the area. In contrast with blood and bone marrow, which were chromosomally normal, all cells of the lymph node were chromosomally abnormal, with numerous clones having multiple structural abnormalities. Numerical abnormalities (trisomies and monosomies) were not found. Structural abnormalities included translocations, terminal deletions, and pericentric inversions, with an excess of centromeric breakpoints being the only apparent deviation from a random distribution of breakpoints. None of the rearrangements associated with malignant lymphoma were seen, indicating that the chromosome abnormalities in the lymph stroma were radiation-associated, not disease-associated. These acquired changes may be a cause of additional malignant transformation.
- Research Organization:
- Long Island Jewish Medical Center, New Hyde Park, NY (USA)
- OSTI ID:
- 5233698
- Journal Information:
- Cancer Genet. Cytogenet.; (United States), Journal Name: Cancer Genet. Cytogenet.; (United States) Vol. 30:2; ISSN CGCYD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INJURIES
IONIZING RADIATIONS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
MUTATIONS
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
X RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
INJURIES
IONIZING RADIATIONS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MEDICINE
MUTATIONS
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SOMATIC CELLS
THERAPY
X RADIATION