Induction of chromosome aberrations by cis-platinum(II)diamminodichloride in Drosophila melanogaster

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Environ. Manage.; (United States)

DOI:https://doi.org/10.1002/em.2860050307· OSTI ID:5233404

Brodberg, R K; Lyman, R F; Woodruff, R C

The authors have determined the in vivo effects of cis-platinum(II)diamminodichloride (cis-PDD) treatment on the induction of chromosome aberrations in Drosophila melanogaster germ cells. cis-PDD treatment induces significant increases in chromosome breakage in all stages of spermatogenesis in a battery of test systems using ring or rod-X males and repair-proficient or deficient females. Since no increase in nondisjunction was induced by cis-PDD in either male or female germ cells, any aneuploidy inducing effects of this compound should result from its clastogenic action. They also find that mei-9 excision repair function is involved in the repair of cis-PDD-induced DNA lesions in a manner that provides additional evidence that partital and ring chromosome losses are not completely homologous.

• Research Organization: Bowling Green State Univ., OH
• OSTI ID: 5233404
• Journal Information: Environ. Manage.; (United States), Journal Name: Environ. Manage.; (United States) Vol. 5:3; ISSN EMNGD
• Country of Publication: United States
• Language: English

Related Subjects

560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEUPLOIDY
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHLORIDES
CHLORINE COMPOUNDS
CHROMOSOMAL ABERRATIONS
DIPTERA
DNA
DROSOPHILA
FLIES
FRUIT FLIES
GAMETOGENESIS
GENETIC EFFECTS
GERM CELLS
HALIDES
HALOGEN COMPOUNDS
IN VIVO
INSECTS
INVERTEBRATES
MUTANTS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM CHLORIDES
PLATINUM COMPOUNDS
PLOIDY
RECOVERY
REPAIR
SPERMATOGENESIS
TRANSITION ELEMENT COMPOUNDS