Induction of chromosome aberrations by cis-platinum(II)diamminodichloride in Drosophila melanogaster
The authors have determined the in vivo effects of cis-platinum(II)diamminodichloride (cis-PDD) treatment on the induction of chromosome aberrations in Drosophila melanogaster germ cells. cis-PDD treatment induces significant increases in chromosome breakage in all stages of spermatogenesis in a battery of test systems using ring or rod-X males and repair-proficient or deficient females. Since no increase in nondisjunction was induced by cis-PDD in either male or female germ cells, any aneuploidy inducing effects of this compound should result from its clastogenic action. They also find that mei-9 excision repair function is involved in the repair of cis-PDD-induced DNA lesions in a manner that provides additional evidence that partital and ring chromosome losses are not completely homologous.
- Research Organization:
- Bowling Green State Univ., OH
- OSTI ID:
- 5233404
- Journal Information:
- Environ. Manage.; (United States), Vol. 5:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DNA
BIOLOGICAL REPAIR
GERM CELLS
CHROMOSOMAL ABERRATIONS
PLATINUM CHLORIDES
GENETIC EFFECTS
ANEUPLOIDY
DROSOPHILA
IN VIVO
MUTANTS
SPERMATOGENESIS
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
CHLORIDES
CHLORINE COMPOUNDS
DIPTERA
FLIES
FRUIT FLIES
GAMETOGENESIS
HALIDES
HALOGEN COMPOUNDS
INSECTS
INVERTEBRATES
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM COMPOUNDS
PLOIDY
RECOVERY
REPAIR
TRANSITION ELEMENT COMPOUNDS
560304* - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)