Comparison of the subchronic inhalation toxicity of petroleum and oil shale diesel fuel marine

Technical Report · Mon Aug 01 04:00:00 EDT 1983

OSTI ID:5233378

Gaworski, C L; MacEwen, J D; Leahy, H F; Latendresse, J R; Pitts, L L

A standard protocol was developed to investigate the effects of low level long-term inhalation exposure to Petroleum and Oil Shale Fuels. Included in the design of the protocol was the capability to assess the effects immediately after exposure as well as monitor possible recovery or potential oncogenic activity. A continuous type of exposure was chosen. The principal sites of toxicity resulting from exposure to petroleum or shale DFM were the liver and kidney. Mild lung irritation seen in rats exposed to petroleum DFM and mice exposed to shale Diesel Fuel Marine (DFM) was similar in aspect to chronic respiratory disease. The lesion occurred frequently in the respective unexposed control groups and was probably reversible. Hepatocellular vacuolization is a nonspecific change which may indicate excess lipid accumulation. No detrimental liver tissue alterations were noted in male rats; however, increased liver weights in the high dose DFM exposed male rats may indicate a response to the need for additional metabolic capacity from this organ. By far the most striking and consistent effect noted after inhalation of DFM vapors was nephrotoxicity in male rats.

• Research Organization: California Univ., Irvine (USA). Toxic Hazards Research Unit
• OSTI ID: 5233378
• Report Number(s): AD-P-001985/1
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600 -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
DIESEL FUELS
DIGESTIVE SYSTEM
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
GLANDS
INHALATION
INTAKE
KIDNEYS
LIVER
LUNGS
MAMMALS
MATERIALS
MINERAL OILS
NEOPLASMS
OIL SHALES
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
RATS
RECOVERY
RESPIRATORY SYSTEM
RODENTS
SHALE OIL
TOXICITY
VERTEBRATES