90-day vapor inhalation toxicity study of decalin

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(85)90203-9· OSTI ID:6371699

Gaworski, C L; Haun, C C; MacEwen, J D; Vernot, E H; Bruner, R H; Amster, R L; Cowan, Jr, M J

A subchronic 90-day inhalation study was conducted to determine the toxic effects of decalin, a commonly used industrial solvent. Experimental groups consisting of male and female beagle dogs, male and female Fischer-344 rats, and female C57BL/6 mice were continuously exposed to decalin concentrations of 5 or 50 ppm. An unexposed control group was also maintained. All dogs and a portion of each rodent group were sacrificed and examined at exposure termination, while the remaining rodents were held for observation up to 21 months postexposure. No distinct exposure-related lesions were noted in dogs. Dog body weights, organ weights, and blood clinical pathology were also normal. At exposure termination hepatocellular cytoplasmic vacuolization was noted in female mice exposed to both concentrations. This liver tissue change was reversible and was not a significant finding in female mice examined during the 21-month postexposure observation period. In male rats, decalin exposure produced nephropathy characterized by hyaline droplets, necrosis, and intratubular casts. Accentuated tubular degeneration and medullary mineralization were noted in exposed rats held for long-term postexposure observation. There was no associated abnormal increase in mortality nor alterations in serum, blood urea nitrogen, or creatinine levels. Female rats were free of decalin-induced renal damage. There was a slightly greater incidence of commonly occurring pituitary tumors in both mice and rats; however, the tumor incidence was not dose related. The results of this study suggest that the toxic effects of decalin are similar to those previously described for other hydrocarbon solvents and fuels.

• Research Organization: Univ. of California, Irvine
• OSTI ID: 6371699
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 4; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANIMALS
BODY
CYCLOALKANES
DECALIN
DIGESTIVE SYSTEM
DISEASES
DOGS
ENDOCRINE GLANDS
FLUIDS
GASES
GLANDS
HYDROCARBONS
INHALATION
INTAKE
KIDNEYS
LIVER
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PITUITARY GLAND
RATS
RODENTS
SEX DEPENDENCE
TOXICITY
VAPORS
VERTEBRATES