Local proliferation and extrahepatic recruitment of liver macrophages (Kupffer cells) in partial-body irradiated rats
The relative significance of local proliferation and extrahepatic recruitment of Kupffer cells was investigated by partial-body irradiation before the induction of macrophage hyperplasia by zymosan. There was no difference in growth of the Kupffer cells population between nonirradiated rats and rats irradiated with the liver shielded, whereas irradiation of the liver with the rest of the body (bone marrow) shielded resulted in strong inhibition of growth (-61%). Splenectomy combined with bone marrow irradiation inhibited growth to a lesser extent as compared to liver irradiation (-38%). Monocyte and other leukocyte numbers were strongly reduced in peripheral blood and their accumulation in the liver was completely prevented by bone marrow irradiation. Our results demonstrate that local proliferation of resident Kupffer cells represents the predominant source for their increased number during hyperplasia.
- Research Organization:
- Free Univ. of Brussels, Belgium
- OSTI ID:
- 5230957
- Journal Information:
- J. Leukocyte Biol.; (United States), Journal Name: J. Leukocyte Biol.; (United States) Vol. 6; ISSN JLBIE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CELL DIVISION
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
GLANDS
HEMATOPOIETIC SYSTEM
INFLAMMATION
IRRADIATION
LIVER
MACROPHAGES
MAMMALS
MEDICINE
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PHAGOCYTES
RADIATION EFFECTS
RATS
RODENTS
SOMATIC CELLS
SPLENECTOMY
SURGERY
SYMPTOMS
TISSUES
VERTEBRATES
ZYMOSAN