Activity changes of pulmonary macrophages after in vivo exposure to ozone as demonstrated by cell adherence

Journal Article · Tue Dec 31 23:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530887· OSTI ID:5229669

Veninga, T S; Evelyn, P

Macrophages obtained by lavage from the lungs of rats exposed to 0.1 or 0.2 mg/m3 (0.05 or 0.10 ppm) ozone (O3) for 16 h show increased activity as measured in vitro by cell adherence to nylon fiber. A difference in adherence is noticed between macrophages occurring in first or second lung washings. The latter are less sensitive to ozone stimulation. At ozone doses higher than 0.2 mg/m3, the effect disappears and is even negative for second-washing macrophages after exposure of rats to 0.8 mg/m3 (0.4 ppm). The increased activity observed after exposure to the lower levels of O3 is explained as a defensive reaction of the organism. Failure to stimulate activity or a decrease of activity, observed at the higher O3 concentrations, may point to adverse events.

• Research Organization: State Univ. of Groningen, The Netherlands
• OSTI ID: 5229669
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
INHALATION
INTAKE
LAVAGE
LUNGS
MACROPHAGES
MAMMALS
ORGANS
OZONE
PHAGOCYTES
RATS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
SOMATIC CELLS
VERTEBRATES