Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Autoradiographic study of the regional distribution of gastric blood flow in portal hypertensive rats

Journal Article · · Gastroenterology; (USA)
OSTI ID:5225460
; ;  [1]
  1. Univ. Department of Surgery, Glasgow (England)
+ Show Author Affiliations

This study measures regional gastric blood flow in portal hypertensive rats at three separate periods after portal vein ligation using quantitative autoradiography with 14C-labeled iodoantipyrine. The level of corpus mucosal blood flow was significantly reduced in 3-day portal vein-ligated animals compared with sham-operated control animals (30.4 +/- 2.3 vs. 47.1 +/- 5.6 ml/100 g.min). There was no significant difference in corpus mucosal blood flow between portal vein-ligated and sham-operated animals at 7- and 28-day periods, although the level of perfusion was higher in the 28-day portal vein-ligated group. There was no significant difference in antral mucosal or muscle blood flow between portal hypertensive and control animals at any of the study periods. We conclude that the acute period after portal vein ligation is associated with a reduced corpus mucosal microcirculation but that this effect is not sustained in portal hypertensive animals studied at later intervals after portal vein ligation.

OSTI ID:
5225460
Journal Information:
Gastroenterology; (USA), Journal Name: Gastroenterology; (USA) Vol. 97:5; ISSN GASTA; ISSN 0016-5085
Country of Publication:
United States
Language:
English

Similar Records

Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model
Journal Article · Sat Jun 01 00:00:00 EDT 1985 · Am. J. Physiol.; (United States) · OSTI ID:5012837
Regional blood flows by the microsphere method: reproducibility in portal hypertensive rats and influence of a portal vein catheter
Journal Article · Thu Mar 31 23:00:00 EST 1988 · Proc. Soc. Exp. Biol. Med.; (United States) · OSTI ID:6902332
Characterization of renal hyperemia in portal hypertensive rats
Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:5495698

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ANTIPYRETICS
ANTIPYRINE
AUTORADIOGRAPHY
AZOLES
BLOOD FLOW
BLOOD VESSELS
BODY
CARBON 14 COMPOUNDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DISEASES
DRUGS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYPERTENSION
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
MUCOUS MEMBRANES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PERFUSED TISSUES
PYRAZOLES
PYRAZOLINES
RATS
RODENTS
STOMACH
SYMPTOMS
TISSUES
VASCULAR DISEASES
VEINS
VERTEBRATES