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Effect of ascorbic acid on cadmium toxicity in the young coturnix

Journal Article · · J. Nutr.; (United States)
OSTI ID:5225240
; ; ; ;

This study was designed to evaluate the effects of supplements of individual dietary components in altering the toxicity of dietary cadmium. Day-old coturnix (Japanese quail) were fed 75 mg Cd/kg of an adequate purified diet for 2- or 4-week periods. Cadmium produced moderate growth retardation, severe anemia, decreased ash content of the tibia, and deviations from the normal concentrations of zinc, iron, cadmium, copper, and calcium in one or more of the cells or tissues assayed (erythrocyte, liver, kidney, and tibia). Dietary supplements of zinc, iron(III), copper, and L-cysteine-HCl and injected ascorbic acid produced slight to moderate protection against cadmium-induced anemia, whereas iron(II), ascorbic acid, and D-isoascorbic acid had marked effects in preventing the anemia, growth retardation, poor bone mineralization, and perturbations in elemental concentrations of tissues. Chromium, cobalt, selenium, nickel, molybdenum, and pteroylglutamic acid had no effects. Cadmium did not affect the total ascorbate content of the liver. Removal of dietary ethoxyquin did not affect the toxicity of cadmium or the protective effects of ascorbic acid. Initiation of ascorbic acid feeding at 2 weeks was beneficial to birds fed cadmium throughout the 4-week experiment. Under the conditions of these experiments cadmium produced a functional iron deficiency and less clear-cut affects on zinc function. It appears that a primary effect of cadmium was to prevent absorption of dietary iron. 33 references, 6 tables.

Research Organization:
Dept. of Health, Education, and Welfare, Washington, DC
OSTI ID:
5225240
Journal Information:
J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 101; ISSN JONUA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMAL TISSUES
ANIMALS
ASCORBIC ACID
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE TISSUES
CADMIUM
CHEMICAL COMPOSITION
CHEMISTRY
COBALT
CONNECTIVE TISSUE
COPPER
DIGESTIVE SYSTEM
ELEMENTS
ERYTHROCYTES
GLANDS
GROWTH
INGESTION
INHIBITION
INTAKE
IRON
KIDNEYS
LIVER
MATERIALS
METALS
MOLYBDENUM
NICKEL
ORGANS
RESPONSE MODIFYING FACTORS
SELENIUM
SEMIMETALS
TISSUES
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES
VITAMINS
ZINC