In vivo interactions of cadmium with copper, zinc, and iron

Journal Article · Mon Dec 31 23:00:00 EST 1962 · J. Nutr.; (United States)

OSTI ID:5225151

Hill, C H; Matrone, G; Payne, W I; Barber, C W

The chemical similarities between copper, zinc, and cadmium led to the speculation that there existed a copper component of cadmium toxicity in addition to the previously shown zinc component. Cadmium was found to be toxic to chicks at dietary levels of 25 to 400 ppM in a copper- and iron-deficient diet. The toxicity resulted in a reduced growth rate, mortality, microcytic hypochromic anemia, and atony and elongation of the gizzard. The growth depression and gizzard abnormality were corrected by increased dietary zinc. The mortality was reversed by added copper indicating that the speculation which prompted the study was valid. Increased dietary iron partially corrected both the mortality and the growth depression, indicating a previously unsuspected iron component of cadmium toxicity. 13 references, 6 tables.

• Research Organization: North Carolina State College, Raleigh
• OSTI ID: 5225151
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 80:3; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
CADMIUM
CHICKENS
COPPER
ELEMENTS
FOWL
GROWTH
INHIBITION
IRON
METALS
PATHOLOGICAL CHANGES
RESPONSE MODIFYING FACTORS
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES
ZINC