A method for measuring dermal exposure to solvents and fumigants
This study aimed to develop a method for evaluating dermal exposure to deposits of volatile liquids. Telone II, a fumigant containing 1,3-dichloropropene (DCP), was used as an example. The approach included direct monitoring of dermal deposits and estimating the dermal absorbed dose. Charcoal cloth dermal dosimeters were developed for retaining the volatile deposits. Estimates are given for the retention efficiencies to be expected in various field conditions. The dermally absorbed dose is affected by the evaporation rate from the skin and by the percutaneous absorption rate (flux). Both factors were studied by the dermal dosing of ras with Telone, and monitoring evaporation and urine metabolites of cis-DCP. While relatively high flux values were calculated for rat and estimated for man, due to fast evaporation, the estimated absorbed fraction from a localized dermal deposit was less than 0.2%. Charcoal cloth dermal dosimeters and charcoal tubes were used in ten studies to monitor dermal and respiratory exposure of field applicators to Telone. The charcoal cloth dosimeter method is applicable for monitoring dermal exposure to other volatile chemicals also. However, evaluation of the exposure could be associated with relatively large variability, rendering the method semiquantitative.
- Research Organization:
- California Univ., Berkeley, CA (USA)
- OSTI ID:
- 5223296
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
CHLORINATED ALIPHATIC HYDROCARBONS
EVAPORATION
FUMIGANTS
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
MATTER
MEASURING METHODS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SOLVENTS
PESTICIDES
PHASE TRANSFORMATIONS
RATS
RODENTS
SKIN ABSORPTION
SOLVENTS
UPTAKE
VERTEBRATES
VOLATILE MATTER