Influence of radioactive contaminants on absorbed dose estimates for radiopharmaceuticals

Conference · Tue Jan 01 04:00:00 EST 1985

OSTI ID:5219719

Watson, E E; Stabin, M G

Several popular radiopharmaceutical products contain low levels of radioactive contaminants. These contaminants increase the radiation absorbed dose to the patient without any increased benefit and, in some cases, with a decrease in image quality. The importance of a contaminant to the radiation dosimetry picture is a function of (1) the contaminant level, (2) the physical half-life of the contaminant, (3) the organ uptake and the biological half-time of the contaminant in the various body systems, and (4) the decay mode, energy, etc. of the contaminant. The general influence of these parameters is discussed in this paper; families of curves are included that reflect the changing importance of contaminant dosimetry with respect to the primary radionuclide as a function of these variables. Several specific examples are also given of currently used radiopharmaceutical products which can contain radioactive contaminants (I-123, In-111, Tl-201, Ir-191m, Rb-82, Au-195m). 7 refs., 8 figs., 4 tabs.

• Research Organization: Oak Ridge Associated Universities, Inc., TN (USA)
• DOE Contract Number: AC05-76OR00033
• OSTI ID: 5219719
• Report Number(s): CONF-851113-7; ON: DE87000309
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BODY
BONE MARROW
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOSES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
GOLD 195
GOLD ISOTOPES
HEART
HEAVY NUCLEI
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
IMPURITIES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSES
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
THYROID
TISSUES
YEARS LIVING RADIOISOTOPES