Direct measurement of reoxygenation in malignant mammary tumors after a single large dose of irradiation

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Adv. Exp. Med. Biol.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-4895-5_76· OSTI ID:5218655

Vaupel, P; Frinak, S; O'Hara, M

Measurements of the tissue O/sub 2/ partial pressure distribution in C3H mouse mammary adenocarcinomas were performed just before and 72 - 74 hrs. after X- irradiation using O/sub 2/ microelectrodes of the gold in glass type. The results obtained before irradiation were similar to those usually obtained previously in fast growing murine tumors during advanced growth stages. After exposure to a single dose of 60 Gy, the distribution curve significantly changed. This change was particularly evident in the very low pO/sub 2/ range which is of crucial importance for the efficacy of radiotherapy. Due to this improvement of the tumor tissue oxygenation the number of radioresistant cells can be drastically reduced in the post- irradiation period at the time of maximum reoxygenation. Judiciously chosen fractionated treatment regimens, thus, should maintain tumor cells in optimum radiosensitivity states.

• Research Organization: Univ. of Mainz, Germany, F.R.
• OSTI ID: 5218655
• Journal Information: Adv. Exp. Med. Biol.; (United States), Journal Name: Adv. Exp. Med. Biol.; (United States); ISSN AEMBA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANOXIA
BODY
CARCINOMAS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL NEOPLASMS
GLANDS
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MEASURING METHODS
MEDICINE
MICE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
ORGANS
OXYGEN
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
SIDE EFFECTS
THERAPY
VERTEBRATES
X RADIATION