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Selective enhancement of radiation response in a C3H mammary carcinoma by cisplatin

Journal Article · · Cancer Treat. Rep.; (United States)
OSTI ID:5657978
;
The interaction between cisplatin and radiation was studied in a C3H mammary carcinoma and its surrounding normal skin. Treatment with 6 mg/kg of cisplatin given 30 mins before irradiation enhanced the radiation response in the tumor by a factor of 1.7, whereas the same drug treatment given immediately after or 4 hrs after irradiation only enhanced the effect by a factor of 1.2--1.3. No interaction between radiation and cisplatin was observed in the surrounding skin. It is hypothesized that in the C3H mammary carcinoma the prominent radiation-modifying effect of cisplatin given before radiation is due to a radiosensitization involving hypoxic tumor cells combined with a tumor cell-destructive effect of the drug itself.
OSTI ID:
5657978
Journal Information:
Cancer Treat. Rep.; (United States), Journal Name: Cancer Treat. Rep.; (United States) Vol. 65:5-6; ISSN CTRRD
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
EXTERNAL IRRADIATION
GLANDS
IRRADIATION
LOCAL IRRADIATION
MAMMARY GLANDS
NEOPLASMS
ORGANS
PATIENTS
PLATINUM COMPOUNDS
RADIATION EFFECTS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
SKIN
TIME DEPENDENCE
TRANSITION ELEMENT COMPOUNDS
TUMOR CELLS