Model for comparison of animal and human alveolar dose and toxic effect of inhaled ozone

Technical Report · Mon Feb 01 04:00:00 EST 1988

OSTI ID:5212693

Hatch, G E; Koren, H; Aissa, M

Present models for predicting human pulmonary toxicity of ozone from the toxic effects observed in animals rely on dosimetric measurements of ozone mass balance, and species comparisons of tissue-protective mechanisms against ozone. The goal of this study was to identify a method to directly compare ozone dose and effect in animals and humans using bronchoalveolar lavage (BAL) fluid markers. Feasibility of estimating ozone dose to lung alveoli was demonstrated through assay of reaction products of oxygen-18-labeled ozone in lung surfactant and macrophage pellets of rabbits. Feasibility of using BAL protein measurements to quantify the ozone toxic response in humans was demonstrated by the finding of significantly increased BAL protein in 10 subjects exposed to 0.4 ppm ozone for 2 hr with intermittant periods of heavy exercise.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 5212693
• Report Number(s): PB-88-171194/XAB; EPA-600/D-88/039
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AIR POLLUTION
COMPARATIVE EVALUATIONS
DOSE LIMITS
INHALATION
INTAKE
MATHEMATICAL MODELS
OZONE
POLLUTION
RESPIRATORY SYSTEM
SAFETY STANDARDS
STANDARDS
TOXICITY