Epidermal growth factor-like proteins in breast fluid and human milk

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90041-0· OSTI ID:5210188

Connolly, J M; Rose, D P

Epidermal growth factor (EGF), and the transforming growth factor-..cap alpha.. (TGF-..cap alpha..) family of proteins, which also bind to the EGF receptor, have been associated with human breast cancer. The total EGF-like proteins were determined by a radioreceptor assay, and TGF-..cap alpha.. by radioimmunoassay, in human milk and breast fluid samples. The breast fluids were collected by nipple aspiration from health premenopausal women. Both the 24 milks and 18 breast fluids assayed contained EGF-like proteins, at concentrations ranging from 32-600 ng/ml and 62-654 ng/ml respectively. Immunoreactive TGF-..cap alpha.. proteins were detected at higher levels in 21 breast fluids than in 24 milk samples.

• Research Organization: American Health Foundation, Valhalla, NY (USA)
• OSTI ID: 5210188
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 42:18; ISSN LIFSA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
DISEASES
FOOD
GLANDS
GROWTH FACTORS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MAMMARY GLANDS
MAN
MATERIALS
MILK
MITOGENS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIORECEPTOR ASSAY
TRACER TECHNIQUES
VERTEBRATES