Epidermal growth factor-like proteins in breast fluid and human milk

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90041-0· OSTI ID:5210188

Connolly, J M; Rose, D P

Epidermal growth factor (EGF), and the transforming growth factor-..cap alpha.. (TGF-..cap alpha..) family of proteins, which also bind to the EGF receptor, have been associated with human breast cancer. The total EGF-like proteins were determined by a radioreceptor assay, and TGF-..cap alpha.. by radioimmunoassay, in human milk and breast fluid samples. The breast fluids were collected by nipple aspiration from health premenopausal women. Both the 24 milks and 18 breast fluids assayed contained EGF-like proteins, at concentrations ranging from 32-600 ng/ml and 62-654 ng/ml respectively. Immunoreactive TGF-..cap alpha.. proteins were detected at higher levels in 21 breast fluids than in 24 milk samples.

• Research Organization: American Health Foundation, Valhalla, NY (USA)
• OSTI ID: 5210188
• Journal Information: Life Sci.; (United States), Vol. 42:18
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GROWTH FACTORS
RADIOIMMUNOASSAY
RADIORECEPTOR ASSAY
MAMMARY GLANDS
NEOPLASMS
IMMUNE REACTIONS
MAN
MILK
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
DISEASES
FOOD
GLANDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques