Lymphocyte transformation as a model system. Final report, January 1, 1980-December 31, 1980
Technical Report
·
OSTI ID:5206597
The following investigations were conducted during the period of this grant: measurement of the insertion of oxygenated sterol compounds (OSC) into human red cells and lymphocyte membranes; the relationship of such insertion to functional and morphological alterations such as echinocyte formation and decreased osmotic fragility in red cells, and inhibition of E-rosette formation and lymphocyte capping in human lymphocytes; a study of the binding of OSC by various lipoprotein fractions of human serum; a study of the effects of human serum lipoprotein on the insertion of OSC into red cell and lymphocyte membranes; a study of the effects of OSC and ML-236B (Compactin) on human lymphocyte proliferation in vitro; a study of the effects of OSC and ML-236B on the synthesis of sterol and nonsterol derived products of mevalonic acid in human lymphocytes; a study of the initiation of cell growth in human lymphocytes by mevalonic acid; and a study of the inhibition of the formation of CFU-C in vitro from human bone marrow mononuclear cells by OSC and ML-236.
- Research Organization:
- Franklin McLean Memorial Research Inst., Chicago, IL (USA)
- DOE Contract Number:
- AC02-80EV10357
- OSTI ID:
- 5206597
- Report Number(s):
- DOE/EV/10357-1; ON: DE82011872
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550300 -- Cytology
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
BONE MARROW CELLS
CELL CONSTITUENTS
CELL MEMBRANES
CELL PROLIFERATION
CFU
CONNECTIVE TISSUE CELLS
DIFFUSION
ERYTHROCYTES
FUNCTIONS
HYDROXY COMPOUNDS
IN VITRO
LEUKOCYTES
LIPIDS
LIPOPROTEINS
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANES
MORPHOLOGICAL CHANGES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OSMOSIS
PRIMATES
PROTEINS
SOMATIC CELLS
STEROIDS
STEROLS
SYNTHESIS
ULTRASTRUCTURAL CHANGES
VERTEBRATES
550300 -- Cytology
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY FLUIDS
BONE MARROW CELLS
CELL CONSTITUENTS
CELL MEMBRANES
CELL PROLIFERATION
CFU
CONNECTIVE TISSUE CELLS
DIFFUSION
ERYTHROCYTES
FUNCTIONS
HYDROXY COMPOUNDS
IN VITRO
LEUKOCYTES
LIPIDS
LIPOPROTEINS
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MEMBRANES
MORPHOLOGICAL CHANGES
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OSMOSIS
PRIMATES
PROTEINS
SOMATIC CELLS
STEROIDS
STEROLS
SYNTHESIS
ULTRASTRUCTURAL CHANGES
VERTEBRATES