High yield synthesis of 6-(18F)fluoro-L-dopa

Journal Article · Sat Mar 01 04:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:5205942

Chirakal, R; Firnau, G; Garnett, E S

The radiofluorination of L-dopa with (/sup 18/F)F2 was investigated with the purpose of improving the yield of 6-(/sup 18/F)fluoro-L-dopa. When boron trifluoride was added to the reaction mixture in hydrogen fluoride (HF), the yield was increased threefold. Nine millicuries of 6-(/sup 18/F)fluoro-L-dopa were produced from 100 mCi (/sup 18/F)F2 routinely and reliably after 2 hr of preparation. If acetonitrile or water were substituted for HF, little or no 6-fluoro-L-dopa was made.

• Research Organization: McMaster Univ. Medical Centre, Hamilton, Ontario
• OSTI ID: 5205942
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ARSENIC
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORANES
BORON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHEMICAL REACTIONS
DOPA
DRUGS
ELEMENTS
FLUORINATION
FLUORINE 18
FLUORINE ISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
HYDRIDES
HYDROGEN COMPOUNDS
HYDROXY ACIDS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SILICON COMPOUNDS
RADIOISOTOPES
SEMIMETALS
SILANES
SILICON COMPOUNDS
SYNTHESIS
YIELDS