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Metabolites of 6-(/sup 18/F)fluoro-L-dopa in human blood

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5173643
; ; ; ;
The metabolites of 6-(/sup 18/F)fluoro-L-dopa in the blood plasma of healthy humans have been identified as 3-O-sulfato-6(/sup 18/F)fluoro-L-dopa, 3-O-methyl-6-(/sup 18/F)fluoro-L-dopa, 6-(/sup 18/F) fluorodopamine, and 6-(/sup 18/F)fluorohomovanillic acid. The time course of these metabolites was followed up to 2 hr. The findings have implications for the use of 6-(/sup 18/F)fluoro-L-dopa as tracer for cerebral dopamine metabolism. Despite the variety of metabolites in the peripheral blood there are only two /sup 18/F-carrying compounds, 6-(/sup 18/F)fluoro-L-dopa and 3-O-methyl-6-(/sup 18/F)fluoro-L-dopa, that can cross the blood-brain barrier. After 1 hr, the plasma concentration of 3-O-methyl-6-(/sup 18/F)fluoro-L-dopa reaches approximately 20% that of 6-(/sup 18/F)fluoro-L-dopa but the mean concentration of the O-methylated metabolite over the same interval is less than 5% that of 6-(/sup 18/F)-fluoro-L-dopa.
Research Organization:
McMaster Univ. Medical Centre, Hamilton, Ontario (Canada)
OSTI ID:
5173643
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:3; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD-BRAIN BARRIER
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DOPA
DOPAMINE
DRUGS
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
MATERIALS
METABOLISM
METABOLITES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PRIMATES
RADIOISOTOPES
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES