Imaging of lymph node uptake after intravenous administration of indium-111 metalloporphyrins
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5205804
Indium-111- (111In) labeled tetra (N,N,N-trimethylanilinium) porphyrin (TTAP), tetra (N-methyl-4-pyridyl)porphyrin (TMPyP), and tetra(4-sulfonatophenyl)porphyrin (T4SPP) were synthesized and lymph node uptake was measured in animals after intravenous administration. In rats (111In) TTAP had maximum lymph node to muscle uptake ratios which averaged 85:1 between 24 and 48 hr postinjection. Total lymph node uptake was nearly 1% at that time. Lymph nodes in rabbits were clearly visualized by gamma scintigraphy at 48 hr after i.v. injection of labeled TTAP. These results suggest that 111In-labeled TTAP may be a prototype for the development of a class radiopharmaceuticals which permits visualization of lymph nodes after i.v. administration.
- Research Organization:
- Univ. of Pennsylvania School of Medicine, Philadelphia
- OSTI ID:
- 5205804
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 2; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES