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MLE (Maximum Likelihood Estimator) reconstruction of a brain phantom using a Monte Carlo transition matrix and a statistical stopping rule

Conference ·
OSTI ID:5205389
; ;
In order to study properties of the Maximum Likelihood Estimator (MLE) algorithm for image reconstruction in Positron Emission Tomographyy (PET), the algorithm is applied to data obtained by the ECAT-III tomograph from a brain phantom. The procedure for subtracting accidental coincidences from the data stream generated by this physical phantom is such that he resultant data are not Poisson distributed. This makes the present investigation different from other investigations based on computer-simulated phantoms. It is shown that the MLE algorithm is robust enough to yield comparatively good images, especially when the phantom is in the periphery of the field of view, even though the underlying assumption of the algorithm is violated. Two transition matrices are utilized. The first uses geometric considerations only. The second is derived by a Monte Carlo simulation which takes into account Compton scattering in the detectors, positron range, etc. in the detectors. It is demonstrated that the images obtained from the Monte Carlo matrix are superior in some specific ways. A stopping rule derived earlier and allowing the user to stop the iterative process before the images begin to deteriorate is tested. Since the rule is based on the Poisson assumption, it does not work well with the presently available data, although it is successful wit computer-simulated Poisson data.
Research Organization:
Lawrence Berkeley Lab., CA (USA); California Univ., Los Angeles (USA). Dept. of Radiological Sciences
DOE Contract Number:
AC03-76SF00098
OSTI ID:
5205389
Report Number(s):
LBL-23357; CONF-871006-51; ON: DE88008219
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
99 GENERAL AND MISCELLANEOUS
990220 -- Computers
Computerized Models
& Computer Programs-- (1987-1989)
ALGORITHMS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED SIMULATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
IMAGE PROCESSING
IMAGES
MATHEMATICAL LOGIC
MATHEMATICS
MATRICES
MOCKUP
MONTE CARLO METHOD
NERVOUS SYSTEM
ORGANS
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
SIMULATION
STATISTICS
STRUCTURAL MODELS
TOMOGRAPHY