Concentration-dependence of the effect of an in situ oil shale retort-produced water on metabolism

Journal Article · Sat Dec 01 04:00:00 EST 1979 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01770036· OSTI ID:5201826

Nelson, K F; North, D S; Farrier, D S

During the conduction of the Rock Springs Site 9 experiment a large volume of retort water was collected to support environmental research studies. This sample was designated Omega-9 retort water. The Omega-9 water has the following characteristics: pH 8.6, 1003 mg/1 total organic carbon, and 30,300 mg/1 of total dissolved solids which are principally bicarbonate, sodium, ammonium, thiosulfate, sulfate, chloride, and carbonate. Although the Omega-9 water cannot be ascribed as typical of in situ oil shale retort waters in general, its availability has supported numerous investigations into the treatment, disposal, use, and effects of such water. It is reported that consumption of undiluted Omega-9 water by 60 to 80 g Holtzman rats led to an increased rate of metabolism of hexobarbital in vivo and in vitro, an increased rate of metabolism of ethylmorphine in vitro, and an increased level of cytochrome P-450 activity. These observations indicated that Omega-9 water induced liver enzymes activity. The purpose of this study was to determine if the induction effect is concentration related.

• Research Organization: Univ. of Wyoming, Laramie
• OSTI ID: 5201826
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 23:6; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040400* -- Oil Shales & Tar Sands-- Oil Production
Recovery
& Refining
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID CARBONATES
ALKALI METALS
AMMONIUM COMPOUNDS
ANIMALS
BIOLOGICAL EFFECTS
BITUMINOUS MATERIALS
CARBON
CARBON COMPOUNDS
CARBONACEOUS MATERIALS
CARBONATES
CHEMICAL REACTORS
CHLORIDES
CHLORINE COMPOUNDS
ELEMENTS
ENERGY SOURCES
ENZYMES
FOSSIL FUELS
FUELS
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
IN-SITU PROCESSING
IN-SITU RETORTING
INDUSTRIAL PLANTS
INDUSTRY
MAMMALS
METABOLISM
METALS
NONMETALS
OIL SHALE INDUSTRY
OIL SHALE PROCESSING PLANTS
OIL SHALES
OXYGEN COMPOUNDS
PROCESSING
QUANTITY RATIO
RATS
RETORTING
RETORTS
RODENTS
SODIUM
SULFATES
SULFUR COMPOUNDS
THIOSULFATES
VERTEBRATES
WATER