Effect of an in-situ-produced oil shale processing water on metabolism
Conference
·
· Am. Chem. Soc., Div. Environ. Chem., Prepr.; (United States)
OSTI ID:5047336
- Univ. of Wyoming, Laramie
Effect of an in-situ produced oil shale processing water on metabolism and on liver enzyme activities in rats were studied by allowing rats to consume retort water. When rats were injected with sodium hexobarbital, at 125 mg/kg of body weight, the length of sleep time in rats drinking retort water was less than control rats drinking tap water. Sodium hexobarbital was metabolized by liver homogenates in vitro at a faster rate by rats drinking retort water than those drinking tap water. In-vivo and in-vitro studies showed no change in the rate of metabolism of zoxazolamine pretreated with retort water. Ethylmorphine demethylation activity was significantly increased in liver microsomes obtained from rats maintained on retort water. Concentrations of terminal cytochrome P-450 were considerably higher in animals pretreated with retort water, but protein levels were not significantly higher. The data indicate that retort water is a Type I inducer.
- OSTI ID:
- 5047336
- Conference Information:
- Journal Name: Am. Chem. Soc., Div. Environ. Chem., Prepr.; (United States) Journal Volume: 18:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
04 OIL SHALES AND TAR SANDS
040700* -- Oil Shales & Tar Sands-- Health & Safety
041000 -- Oil Shales & Tar Sands-- Environmental Aspects
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
CYTOCHROMES
DIGESTIVE SYSTEM
DRUGS
ENERGY SOURCES
ENZYME ACTIVITY
FOSSIL FUELS
FUELS
GLANDS
HYDROGEN COMPOUNDS
IN VIVO
IN-SITU PROCESSING
IN-SITU RETORTING
LIQUID WASTES
LIVER
MAMMALS
METABOLISM
OIL SHALES
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PIGMENTS
PROCESSING
PROTEINS
RATS
RETORTING
RODENTS
SODIUM COMPOUNDS
VERTEBRATES
WASTE WATER
WASTES
WATER
040700* -- Oil Shales & Tar Sands-- Health & Safety
041000 -- Oil Shales & Tar Sands-- Environmental Aspects
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
CYTOCHROMES
DIGESTIVE SYSTEM
DRUGS
ENERGY SOURCES
ENZYME ACTIVITY
FOSSIL FUELS
FUELS
GLANDS
HYDROGEN COMPOUNDS
IN VIVO
IN-SITU PROCESSING
IN-SITU RETORTING
LIQUID WASTES
LIVER
MAMMALS
METABOLISM
OIL SHALES
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PIGMENTS
PROCESSING
PROTEINS
RATS
RETORTING
RODENTS
SODIUM COMPOUNDS
VERTEBRATES
WASTE WATER
WASTES
WATER