Dose distribution of neutron beam and chromosome analysis

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90267-2· OSTI ID:5200126

Matsubara, S; Kuwabara, Y; Horiuchi, J; Suzuki, S; Ito, A

Chromosome analysis using peripheral lymphocytes is a sensitive and reliable indicator of the biological effect of radiation at low radiation doses. In the present study, using this chromosome aberration analysis, we tried to investigate the radiation dose distribution within and around the radiation field of a 6 MeV neutron beam. The efficient induction of dicentrics and rings at the irradiation of neutrons compared to those of gamma or X rays especially in a lower dose range, results in a dominant linear component in the linear quadratic model in the dose response relation of a chromosome aberration formation. A marked increase of RBE (relative biological effectiveness) in a lower dose range of neutrons was demonstrated. The radiation doses of the neutron beam as a function of depth, estimated from the yields of dicentrics and rings in a water phantom revealed a fairly good agreement with doses that were physically obtained. The radiation portal margin of the neutron beam was demonstrated to be not as sharp due to a wide penumbra. This wide penumbra and high RBE value, especially at lower dose range of the neutron beam may contribute to the induction of secondary malignancies in the normal tissue surrounding the tumor mass.

• Research Organization: Tokyo Medical and Dental Univ. (Japan)
• OSTI ID: 5200126
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 14:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

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ANIMAL CELLS
BARYONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HADRONS
HYDROGEN COMPOUNDS
IN VITRO
IRRADIATION
LEUKOCYTES
LOW DOSE IRRADIATION
LYMPHOCYTES
MATERIALS
MOCKUP
MUTATIONS
NEUTRON BEAMS
NEUTRONS
NUCLEON BEAMS
NUCLEONS
OXYGEN COMPOUNDS
PARTICLE BEAMS
PHANTOMS
RADIATION DOSE DISTRIBUTIONS
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY
RBE
SOMATIC CELLS
STRUCTURAL MODELS
WATER