Induction of chromosome aberrations in G/sub 0/ human lymphocytes by low doses of ionizing radiations of different quality

Conference · Mon Jul 01 04:00:00 EDT 1985 · Radiat. Res.; (United States)

OSTI ID:5198370

Fabry, L; Leonard, A; Wambersie, A

Human peripheral blood lymphocytes from two donors were exposed to low doses (0.05 to 2.0 Gy) of ..gamma.. rays, X rays, or fast neutrons of different energies. Chromosome aberrations were analyzed in metaphase of first-division cells after a culture time of 45-46 hr. Different dose-response relationships were fitted to the data by using a maximum likelihood method; best fits for radiation-induced dicentric aberrations were obtained with the linear-quadratic law for all radiations. The linear component of this equation predominated, however, for neutrons in the range of doses studied. The RBE increased with decreasing neutron dose and with decreasing neutron energy from d(50)+Be to d(16)+Be neutrons. The limiting RBE at low doses (RBEo) was calculated to be about 1.5 for X rays and 14.0, 6.2, and 4.7 for the d(16)+Be, d(33)+Be, and d(50)+Be neutrons, respectively.

• Research Organization: C.E.N./S.C.K., Mol, Belgium
• OSTI ID: 5198370
• Report Number(s): CONF-860423-
• Conference Information: Journal Name: Radiat. Res.; (United States) Journal Volume: 103:1
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HADRONS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
LOW DOSE IRRADIATION
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MINUTES LIVING RADIOISOTOPES
MUTATIONS
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-ODD NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
SOMATIC CELLS
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES