Neuronal death and synapse elimination in the olivocerebellar system: III. Cell counts in the inferior olive of developing rats X-irradiated from birth
Journal Article
·
· J. Comp. Neurol.; (United States)
The change with age of cell number in the developing inferior olivary nucleus (ION) of the normal rat, compared to the time course of the regression of the polyneuronal innervation of Purkinje cells by olivary axons (i.e., the climbing fibers), suggests that the involution of the redundant olivocerebellar contacts is caused by a reduction of axonal branching rather than by degeneration of the parent cells, this being also suggested by the normal size of the olivary population in adult rodents whose Purkinje cells retain polyneuronal innervation. However, the similar size of the adult ION population does not necessarily imply that the development history is the same in normal and multiply innervated adult rodents. Therefore, cell counts were performed in developing rats which had been repeatedly X-irradiated from birth until postnatal day 14 and which retained polyneuronal innervation. The results show that, although less marked than during normal development, the evolution of the ION population is also characterized by a phase of cell loss followed by a slow increase. However, the number of cells in X-irradiated rats is higher than in their controls from birth to postnatal day 15 but becomes identical at 20 days and later. These data confirm that cell death in the ION does not play a major role in the shaping of olivocerebellar connections.
- Research Organization:
- Institut Pasteur, Paris (France)
- OSTI ID:
- 5198149
- Journal Information:
- J. Comp. Neurol.; (United States), Journal Name: J. Comp. Neurol.; (United States) Vol. 267:2; ISSN JCNEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CELL CONSTITUENTS
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
CEREBELLUM
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CELL CONSTITUENTS
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
CEREBELLUM
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
VERTEBRATES
X RADIATION