Surfactant secretion and clearance in the newborn

Journal Article · Sun Oct 01 04:00:00 EDT 1989 · Journal of Applied Physiology (1985); (USA)

OSTI ID:5189348

Stevens, P A; Wright, J R; Clements, J A ^[1]

---

1. Univ. of California, San Francisco (USA)

Pregnant rabbits (30 days) were injected intravenously with (3H)choline 8 h before delivery. The fetuses were delivered, and lung lavage and lamellar body phospholipids (PL) were analyzed. Some newborns also received radioactively labeled surfactant intratracheally on delivery and were permitted to breathe. With time, intratracheal label decreased in lavage and appeared in the lamellar body fraction, and intravenous label accumulated in both pools. Using a tracer analysis for non-steady state, we calculated surfactant secretion and clearance rates for the newborn period. Before birth, both rates rose slightly from 1.8 micrograms PL.g body wt-1.h-1 at 6 h before birth to 7.3 at birth. Immediately after birth, secretion rate rose to 37.7 micrograms PL.g body wt-1.h-1. Between 1.5 and 2 h after birth it fell to a minimum of 1.8 micrograms PL.g body wt-1.h-1 and then rose slowly to 6.0 at 12 h. After birth, clearance rate increased less than secretion rate (maximum 24.7 micrograms PL.g body wt-1.h-1 shortly after birth) then followed the same pattern but did not balance secretion rate in the 1st day.

• OSTI ID: 5189348
• Journal Information: Journal of Applied Physiology (1985); (USA), Journal Name: Journal of Applied Physiology (1985); (USA) Vol. 67:4; ISSN 8750-7587; ISSN JAPHE
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMALS
BODY
CHOLINE
CLEARANCE
DRUGS
ENZYMES
ESTERS
FETUSES
HEMIACETAL DEHYDROGENASES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LACTATE DEHYDROGENASE
LAVAGE
LIPIDS
LIPOTROPIC FACTORS
LUNGS
MAMMALS
NEONATES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHOSPHOLIPIDS
PREGNANCY
QUATERNARY COMPOUNDS
RABBITS
RESPIRATORY SYSTEM
SECRETION
SURFACTANTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES