Localization of gonadotropin binding sites in human ovarian neoplasms

Journal Article · Sun Oct 01 04:00:00 EDT 1989 · American Journal of Obstetrics and Gynecology; (USA)

DOI:https://doi.org/10.1016/0002-9378(89)90749-7· OSTI ID:5187749

Nakano, R; Kitayama, S; Yamoto, M; Shima, K; Ooshima, A ^[1]

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1. Wakayama Medical College (Japan)

The binding of human luteinizing hormone and human follicle-stimulating hormone to ovarian tumor biopsy specimens from 29 patients was analyzed. The binding sites for human luteinizing hormone were demonstrated in one tumor of epithelial origin (mucinous cystadenoma) and in one of sex cord-stromal origin (theca cell tumor). The binding sites for human follicle-stimulating hormone were found in three tumors of epithelial origin (serous cystadenoma and mucinous cystadenoma) and in two of sex cord-stromal origin (theca cell tumor and theca-granulosa cell tumor). The surface-binding autoradiographic study revealed that the binding sites for gonadotropins were localized in the stromal tissue. The results suggest that gonadotropic hormones may play a role in the growth and differentiation of a certain type of human ovarian neoplasms.

• OSTI ID: 5187749
• Journal Information: American Journal of Obstetrics and Gynecology; (USA), Journal Name: American Journal of Obstetrics and Gynecology; (USA) Vol. 161:4; ISSN AJOGA; ISSN 0002-9378
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
BODY
DISEASES
FEMALE GENITALS
FSH
GONADOTROPINS
GONADS
HORMONES
IODINE ISOTOPES
ISOTOPES
KINETICS
MEMBRANE PROTEINS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
REACTION KINETICS
RECEPTORS