Mechanisms associated with the toxicity of polyhalogenated cyclic hydrocarbons and heavy metals. Final report, 1 November 1993-31 October 1996
We have hypothesize that the toxic manifestations of polyhalogenated cyclic hydrocarbons and heavy metals are at least in part induced through a series of events involving the production of reactive oxygen species, activation of the protein kinase C system and release of tumor necrosis factor-a (TNFa). The sequence of these events is not known, and the relationship between these events and the induction of stress protein has not been studied. Both in vivo and in vitro effects on these parameters as well as acute and chronic studies will be determined. The above hypothesis will be tested by completing the following specific aims. Excellent progress has been made relative to the specific objectives of this research project. Based on the results which have been completed during the past three years, 21 manuscripts were published or are in press in refereed journals, and 14 presentations have been made at national and international scholarly meetings.
- Research Organization:
- Creighton Univ., Omaha, NE (United States). Health Sciences Center
- OSTI ID:
- 518719
- Report Number(s):
- AD-A-325697/1/XAB; CNN: Contract F49620-94-1-0048; TRN: 72240537
- Resource Relation:
- Other Information: PBD: Oct 1996
- Country of Publication:
- United States
- Language:
- English
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