Genetic architecture of autosome-mediated hybrid male sterility in Drosophila

Journal Article · Mon Apr 01 04:00:00 EST 1996 · Genetics

OSTI ID:518186

Marin, I ^[1]

---

1. Stanford Univ., CA (United States)

Several estimators have been developed for assesing the number of sterility factors in a chromosome based on the sizes of fertile and sterile introgressed fragments. Assuming that two factors are required for producing sterility, simulations show that one of these, twice the inverse of the relative size of the largest fertile fragment, provides good average approximations when as few as five fertile fragments are analyzed. The estimators have been used for deducing the number of factors from previous data on several pairs of species. A particular result contrasts with the authors` interpretations: instead of the high number of sterility factors suggested, only a few per autosome are estimated in both reciprocal crosses involving Drosophila buzzatii and D. koepferae. It has been possible to map these factors, between three and six per chromosome, in the autosomes 3 and 4 of these species. Out of 203 introgressions of different fragments or combinations of fragments, the outcome of at least 192 is explained by the mapped zones. These results suggest that autosome-mediated sterility in the male hybrids of these species is mediated by a few epistatic factors, similarly to X-mediated sterility in the hybrids of other Drosophila species. 48 refs., 5 tabs.

• OSTI ID: 518186
• Journal Information: Genetics, Journal Name: Genetics Journal Issue: 4 Vol. 142; ISSN GENTAE; ISSN 0016-6731
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL EVOLUTION
CHROMOSOMES
DROSOPHILA
FUNCTIONAL MODELS
GENETIC MAPPING
HEREDITARY DISEASES
HYBRIDIZATION
PHENOTYPE
SIMULATION
STERILITY